การตรวจคัดเลือกพันธุกรรมก่อนการฝังตัว (PGT)

PGT (Preimplantation Genetic Testing)

Genetic screening before implantation (PGT: Preimplantation Genetic Testing)

Nowadays, infertility treatment technology has progressed to the stage where genetic disease can be diagnosed before embedding into the uterus. This technology can increase the chances of pregnancy, get healthy child and reduce miscarriage rates due to genetic abnormalities in babies.

In general, genetic examination (Genetic Disorder) is divided into 2 types:

  1. Preimplantation Genetic Testing for Aneuploidy (PGT-A) : Used to detect abnormalities in chromosome levels.
  2. Preimplantation Genetic Testing for Monogenic Disease (PGT-M) : Used to detect abnormal diseases at the gene level.

 

Chromosome Abnormalities

In human, each cell normally contains 23 pairs of chromosomes, for a total of 46. Chromosome no.1 – Chromosome no.22 is Autosome chromosome that control genetic and various characteristics of the body. While Chromosome no.23 is sex chromosome that control sex or determine the gender

 

Chromosomal abnormalities can be divided into 2 groups, namely the number of chromosomes (Numerical) causing abnormalities in the body or brain, such as having a double chromosome number 13, 18, and 21 causing Patau Syndrome, Edwards Syndrome and Down Syndrome respectively. Another group is structural chromosomes (abnormal), such as the switching of the position of chromosome (Translocation) causes abnormal reproduction cell, infertility and recurrent miscarriage.

 

Preimplantation Genetic Testing for Aneuploidy (PGT-A)

Chromosome Abnormalities can be analyzed by using a method called PGS (Preimplantation Genetic Screening) or nowadays called as PGT-A (Preimplantation Genetic Testing for Aneuploidy). PGT-A can detect genetic diseases caused by the number of chromosomes missing or exceeded. In addition, it is also used to detect the condition that has been switched to chromosome position.

 

Smile IVF Clinic provides services for diagnosis of chromosomal abnormalities with the technique of
Next Generation Sequencing (NGS) Technique, can be considered as the latest technology to achieve high accuracy results (99.9%).

 

 

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